DeepAden - Adenylation Domain Substrate Specificity Prediction

Input FASTA sequence

Please copy and paste one or multiple FASTA sequences below.

Or upload a FASTA file.

top_k max_separation

Note: When max_separation is selected, the tool will use the GMM model to calculate statistically significant best candidate substrates. When top_k is selected, the tool will output the top 10 candidate substrates.

Optional: upload your own substrate file(s) in SMILES format

Yes

Email address (optional, results will be sent here)

Reference

Jiaquan Huang#, Liangjun Ge#, Yaxin Wu#, Qiandi Gao, Pan Li, Jun Wu, Heqian Zhang*, Zhiwei Qin*. DeepAden: an explainable machine learning for substrate specificity prediction in nonribosomal peptide synthetases. BioRxiv. https://doi.org/10.1101/2025.05.21.655435

Contact: z.qin@bnu.edu.cn, zhangheqian@bnu.edu.cn